Open AccessImmunoglobulin G4 ‐related disease presenting as a pulmonary nodule with an irregular margin
Author(s) -
Okubo Tetsuyuki,
Oyamada Yumiko,
Kawada Masaya,
Kawarada Yo,
Kitashiro Shuji,
Okushiba Shunichi
Publication year - 2017
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.208
Subject(s) - medicine , pathology , nodule (geology) , immunostaining , solitary pulmonary nodule , igg4 related disease , lung , positron emission tomography , antibody , computed tomography , infiltration (hvac) , pulmonary fibrosis , fibrosis , radiology , immunohistochemistry , immunology , paleontology , physics , thermodynamics , biology
We report a case of immunoglobulin G4 ( IgG4 )‐related lung disease presenting as a solitary pulmonary nodule with an irregular margin on computed tomography. The nodule showed a high standardized uptake value on positron emission tomography. A malignant pulmonary tumour could not be excluded. Middle lobectomy was performed. Histological analysis revealed marked lymphoplasmacytic infiltration and storiform fibrosis. Immunostaining indicated the presence of IgG4 ‐positive plasma cells. A definitive diagnosis of IgG4 ‐related disease was confirmed.