Open AccessThe IRIS paradox: Imaging findings in a case of PJP‐IRIS
Author(s) -
Reddy Taryn,
Bajwa Ramey,
Burke Andrew
Publication year - 2022
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.1014
Subject(s) - immune reconstitution inflammatory syndrome , medicine , pneumocystis jirovecii , antiretroviral therapy , pneumonia , iris (biosensor) , immune system , immunology , human immunodeficiency virus (hiv) , viral load , computer security , biometrics , computer science
Immune reconstitution inflammatory syndrome (IRIS) in patients with human immunodeficiency virus (HIV) and Pneumocystis jirovecii pneumonia infection reflects an exaggerated inflammatory response of the host immune system to an antigen, which is temporally related to recovery of the immune system. Clinical manifestations include fever, cough, dyspnoea and hypoxia following the commencement of antiretroviral therapy. Diagnosis is made on clinical and radiological criteria with exclusion of other infective and non‐infective causes. Unrecognized, IRIS may be associated with significant morbidity and mortality. Treatment with corticosteroids often results in prompt recovery. There is limited literature on radiological findings of Pneumocystis jirovecii pneumonia‐associated IRIS. Here we describe cross‐sectional imaging findings of PJP‐IRIS in a patient following commencement of antiretroviral therapy.