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Determination of trace fluoride in water samples by silylation and gas chromatography/mass spectrometry analysis
Author(s) -
Du Jingru,
Sheng Chunqi,
Wang Yan,
Zhang Huarong,
Jiang Kezhi
Publication year - 2021
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.9089
Subject(s) - chemistry , fluoride , silylation , mass spectrometry , hydrochloric acid , chromatography , reproducibility , gas chromatography , gas chromatography–mass spectrometry , ion , ion chromatography , analytical chemistry (journal) , inorganic chemistry , organic chemistry , catalysis
Rationale Due to the ubiquity of fluorides and the small gap between a safe dose and a harmful one, it is necessary to develop a robust analytical method for determination of fluoride ions in various water samples with complex matrices. Methods Silylation of the fluoride ion was carried out by treatment with hydrochloric acid and phenyldimethylchlorosilane at room temperature. The formed phenyldimethylfluorosilane was detected by gas chromatography/mass spectrometry (GC/MS). Results Under the optimized conditions, linearity in the analytical method ranged from 0.050 to 5.0 μg/mL for the fluoride ion with R 2 >0.9999. Reasonable reproducibility was obtained with the intraday relative standard deviation (RSD) ( N = 5) of 2.04% and interday RSD ( N = 5) of 3.75% at the concentration of 0.10 μg/mL. The developed method has been successfully applied to determine the fluoride ion in real water samples, including waste water samples, with the recovery between 81.12% and 113.04%. Conclusions A robust method for the determination of the fluoride ion has been developed by silylation with phenyldimethylchlorosilane and GC/MS analysis. The established method showed good anti‐interference and precision, and it has been applied for determination of the fluoride ion in various water samples.