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Determination of magnesium isotopic ratios of biological reference materials via multi‐collector inductively coupled plasma mass spectrometry
Author(s) -
Le Goff Samuel,
Albalat Emmanuelle,
Dosseto Anthony,
Godin JeanPhilippe,
Balter Vincent
Publication year - 2021
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.9074
Subject(s) - chemistry , inductively coupled plasma mass spectrometry , mass spectrometry , analytical chemistry (journal) , biological materials , matrix (chemical analysis) , certified reference materials , inductively coupled plasma , sample preparation , isotope , chromatography , detection limit , plasma , physics , quantum mechanics , biological system , biology
Rationale Despite a wide range of potential applications, magnesium (Mg) isotope composition has been so far sparsely measured in reference materials with a biological matrix, which is important for the quality control of the results. We describe a method enabling the chemical separation of Mg in geological and biological materials and the determination of its stable isotope composition. Methods Different geological (BHVO‐1, BHVO‐2, BCR‐1, and IAPSO) and biological (SRM‐1577c, BCR‐383, BCR380R, ERM‐CE464, DORM‐2, DORM‐4, TORT‐3, and FBS) reference materials were used to test the performance of a new sample preparation procedure for Mg isotopic analysis. The procedure consisted of a simple three‐stage elution method to separate Mg from the matrix. Mg isotopic analyses were performed in two different laboratories and with three different multi‐collector inductively coupled plasma mass spectrometry instruments. Results The biological reference materials show a wide range of δ 26 Mg values (relative to DSM3 standard), spanning over 2‰, from 0.52 ± 0.29‰ (2SD, n = 7) in bovine liver (SRM‐1577c) to −1.45 ± 0.20‰ (2SD, n = 5) in tuna fish (ERM‐CE464), with an external precision of 0.03‰ (2SD, n = 85). Conclusions This study indicates that isotopic measurements of Mg in biological reference materials show good performance, with the results being within the accepted range. We confirmed that δ 26 Mg values in liver are the most positive of all biological materials reported so far.