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Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionization mass spectrometric bioanalytical methods
Author(s) -
Avery Michael J.
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.895
Subject(s) - chemistry , bioanalysis , analyte , atmospheric pressure chemical ionization , mass spectrometry , direct electron ionization liquid chromatography–mass spectrometry interface , ionization , analytical chemistry (journal) , ion suppression in liquid chromatography–mass spectrometry , chromatography , atmospheric pressure , chemical ionization , ion , ambient ionization , ion source , liquid chromatography–mass spectrometry , oceanography , organic chemistry , geology
Abstract Ion suppression is a known phenomenon in atmospheric pressure ionization mass spectrometry. These suppression effects have been shown to adversely affect the accuracy and precision of quantitative bioanalytical methods. This paper presents a simple procedure for determining the impact of differential ion suppression on bioanalytical methods that utilize atmospheric pressure ionization mass spectrometric (APIMS) detection. This procedure was applied to the assessment of two potential internal standards, and to determine selectivity issues for another analyte which was to be measured in multiple species. Copyright © 2002 John Wiley & Sons, Ltd.