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Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease
Author(s) -
Miletić Vukajlović Jadranka,
Drakulić Dunja,
Pejić Snežana,
Ilić Tihomir V.,
Stefanović Aleksandra,
Petković Marijana,
Schiller Jürgen
Publication year - 2020
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.8595
Subject(s) - lysophosphatidylcholine , chemistry , medicine , pathological , gastroenterology , phosphatidylcholine , endocrinology , phospholipid , biochemistry , membrane
Rationale Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico‐pathological features. Methods The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico‐pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. Results PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico‐pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico‐pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration.