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Fast‐switching high‐voltage porous‐tip electrospray ionization mass spectrometry for rapid detection of antirheumatic drugs in adulterated herbal dietary supplements
Author(s) -
Yao YaNan,
Wu Lin,
Sun WanYang,
Luo ZhiHui,
Di Dandan,
Yuan ZiCheng,
Huang Zhengxu,
Hu Bin
Publication year - 2019
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.8559
Subject(s) - chemistry , electrospray ionization , chromatography , mass spectrometry , analyte , detection limit , electrospray , tandem mass spectrometry , analytical chemistry (journal)
Rationale Herbal dietary supplements (HDSs) adulterated with undeclared synthetic drugs can lead to serious health problems Methods A fast‐switching positive/negative high‐voltage (+/− HV) was developed to apply on electrospray ionization mass spectrometry (ESI‐MS) with porous tips for rapid screening of five antirheumatic drugs in antirheumatic HDSs. The fast‐switching (switch‐time: 100 ms) negative and positive ions were alternately generated to perform full‐MS and tandem‐MS analysis, providing an effective method for rapid detection of analytes in whichever mode of detection was most suitable (negative or positive ion mode). The use of different tips and solvents was also optimized in this work. Results The limits of detection of the five antirheumatic drugs were found to be less than 0.1 ng/g (S/ N > 3). The reproducibility of the five drugs was measured to be 10.0–23.3% ( n = 5). A single sample analysis could be completed within 1 min. Rapid screening of a total of 28 real HDS samples collected from the market was examined by the fast‐switching HV substrate‐tip ESI‐MS method, and the screening result was further validated by conventional liquid chromatography/mass spectrometry. Conclusions Overall, our results demonstrated that fast‐switching HV substrate‐tip ESI‐MS is a rapid, reliable, and effective method for simultaneous screening of various analytes in complex samples.