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Importance of collision cross section measurements by ion mobility mass spectrometry in structural biology
Author(s) -
Pukala Tara
Publication year - 2019
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.8294
Subject(s) - chemistry , mass spectrometry , ion mobility spectrometry , nanotechnology , collision , field (mathematics) , structural biology , underpinning , function (biology) , computational biology , computer science , chromatography , materials science , biochemistry , engineering , evolutionary biology , biology , civil engineering , computer security , mathematics , pure mathematics
The field of ion mobility mass spectrometry (IM‐MS) has developed rapidly in recent decades, with new fundamental advances underpinning innovative applications. This has been particularly noticeable in the field of biomacromolecular structure determination and structural biology, with pioneering studies revealing new structural insight for complex protein assemblies which control biological function. This perspective offers a review of recent developments in IM‐MS which have enabled expanding applications in protein structural biology, principally focusing on the quantitative measurement of collision cross sections and their interpretation to describe higher order protein structures.