Importance of collision cross section measurements by ion mobility mass spectrometry in structural biology | Zendy

Pukala Tara | Zendy

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Importance of collision cross section measurements by ion mobility mass spectrometry in structural biology

Author(s) -

Pukala Tara

Publication year - 2019

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.8294

Subject(s) - chemistry , ion mobility spectrometry , mass spectrometry , collision , section (typography) , ion mobility spectrometry–mass spectrometry , analytical chemistry (journal) , chromatography , tandem mass spectrometry , selected reaction monitoring , computer security , computer science , operating system

The field of ion mobility mass spectrometry (IM‐MS) has developed rapidly in recent decades, with new fundamental advances underpinning innovative applications. This has been particularly noticeable in the field of biomacromolecular structure determination and structural biology, with pioneering studies revealing new structural insight for complex protein assemblies which control biological function. This perspective offers a review of recent developments in IM‐MS which have enabled expanding applications in protein structural biology, principally focusing on the quantitative measurement of collision cross sections and their interpretation to describe higher order protein structures.

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