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Mass spectrometry in drug metabolism and pharmacokinetics: Current trends and future perspectives
Author(s) -
Cuyckens Filip
Publication year - 2019
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.8235
Subject(s) - adme , chemistry , pharmacokinetics , biochemical engineering , mass spectrometry , drug metabolism , drug , drug candidate , pharmacology , drug discovery , computational biology , chromatography , metabolism , biochemistry , medicine , engineering , biology
Drug Metabolism and Pharmacokinetics (DMPK) is a core scientific discipline within drug discovery and development as well as post‐marketing. It helps to design and select the most promising drug candidate and obtain advanced insights on the processes that control absorption, distribution, metabolism and excretion (ADME) of the final drug candidate. Mass spectrometry is one of the key technologies applied in DMPK. Therefore, the continuous advances made in the field of mass spectrometry also directly impact the way in which we investigate the ADME properties of a compound, providing us with new tools to gather more information or improve our efficiency. An overview will be given of some important current trends and future perspectives in the field.