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Multiple sprayer system for high‐throughput electrospray ionization mass spectrometry
Author(s) -
Schneider Bradley B.,
Douglas D. J.,
Chen David D. Y.
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.806
Subject(s) - sprayer , chemistry , electrospray , mass spectrometry , electrospray ionization , ion source , ion , lens (geology) , extractive electrospray ionization , analytical chemistry (journal) , chromatography , optics , sample preparation in mass spectrometry , physics , geotechnical engineering , organic chemistry , engineering
A multiple sprayer electrospray ion source for high‐throughput analysis is described. The ion source is comprised of multiple electrospray capillaries, each with an ion lens located near the tip. The electric potentials applied to the ion lenses are used to control the sprayers. The use of ion lenses eliminates the need for mechanical blocking devices to selectively enable or disable the sprayers, and results in a less expensive and more reliable set‐up. Sprayers can be enabled or disabled within approximately 50–250 ms when the lens potentials are controlled manually. For simultaneous operation of multiple electrospray capillaries, it is advantageous to orient the capillaries so that the spray from each passes directly in front of the entrance aperture of the mass spectrometer. Copyright © 2002 John Wiley & Sons, Ltd.