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Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms
Author(s) -
Yang Xiangkun,
Bartlett Michael G.
Publication year - 2016
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.7462
Subject(s) - chemistry , xenobiotic , mass spectrometry , adduct , toxicity , identification (biology) , environmental chemistry , computational biology , biochemistry , chromatography , organic chemistry , enzyme , botany , biology
The determination of protein‐xenobiotic adducts using mass spectrometry is an emerging area which allows detailed understanding of the underlying mechanisms involved in toxicity. These approaches can also be used to reveal potential biomarkers of exposure or toxic response. The following review covers studies of protein adducts resulting from exposure to a wide variety of xenobiotics including organophosphates, polycyclic aromatic hydrocarbons, acetaminophen, alkylating agents and other related compounds. Copyright © 2016 John Wiley & Sons, Ltd.