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Does thermal degradation occur in laser spray ionization?
Author(s) -
Hiraoka K.,
Asakawa Y.,
Ueda K.,
Hori A.,
Sakai T.,
Okazaki S.,
Nakamura M.
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.687
Subject(s) - chemistry , degradation (telecommunications) , mass spectrometry , laser , ion , chloride , nd:yag laser , sodium , ionization , capillary action , analytical chemistry (journal) , molecule , chromatography , organic chemistry , composite material , optics , telecommunications , physics , materials science , computer science
A laser spray interface for use in liquid chromatography/mass spectrometry (LC/MS) has been investigated with respect to the degradation of the thermally labile compounds, ribostamycin, acetylcholine chloride, and cholesterol 3‐sulfate sodium salt. It was confirmed that few fragment ions were formed when the laser beam was focused at the center of the stainless steel capillary, i.e., no wall heating. When the laser beam was slightly off‐center, the sample ions suffered from thermal degradation by the heated wall of the stainless steel capillary to give fragment ions, which would be useful for the structural elucidation of the sample molecules. Copyright © 2002 John Wiley & Sons, Ltd.