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Low‐mobility‐pass filter between atmospheric pressure chemical ionization and electrospray ionization sources and a single quadrupole mass spectrometer: computational models and measurements
Author(s) -
Menlyadiev Marlen R.,
Tadjimukhamedov Fatkhulla Kh.,
Tarassov Alexander,
Wollnik Hermann,
Eiceman Gary A.
Publication year - 2013
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.6762
Subject(s) - chemistry , quadrupole mass analyzer , ion , mass spectrometry , analytical chemistry (journal) , ionization , electrical mobility , desorption electrospray ionization , ion source , atmospheric pressure chemical ionization , ion trap , quadrupole ion trap , electrospray ionization , ion mobility spectrometry , ambient ionization , waveform , atmospheric pressure , chemical ionization , voltage , chromatography , physics , organic chemistry , quantum mechanics , meteorology
RATIONALE Mixtures of ions produced in sources at atmospheric pressure, including chemical ionization (APCI) and electrospray ionization (ESI) can be simplified at or near ambient pressure using ion mobility based filters. METHODS A low‐mobility‐pass filter (LMPF) based on a simple mechanical design and simple electronic control was designed, modeled and tested with vapors of 2‐hexadecanone in an APCI source and with spray of peptide solutions in an ESI source. The LMPF geometry was planar and small (4 mm wide × 13 mm long) and electric control was through a symmetric waveform in low kHz with amplitude between 0 and 10 V. RESULTS Computational models established idealized performance for transmission efficiency of ions of several reduced mobility coefficients over the range of amplitudes and were matched by computed values from ion abundances in mass spectra. The filter exhibited a broad response function, equivalent to a Bode Plot in electronic filters, suggesting that ion filtering could be done in blocks ~50 m/z units wide. CONCLUSIONS The benefit of this concept is that discrimination against ions of high mobility is controlled by only a single parameter: waveform amplitude at fixed frequency. The effective removal of high mobility ions, those of low mass‐to‐charge, can be beneficial for applications with ion‐trap‐based mass spectrometers to remove excessive levels of solvent or matrix ions. Copyright © 2013 John Wiley & Sons, Ltd.