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Electrospray ionization mass spectrometric studies of phosphorus oxychloride directed synthesis of homo‐oligopeptide ester libraries
Author(s) -
Zhou Ning,
Lu Kui,
Liu Yan,
Chen Yi,
Tang Guo,
Cao ShuXia,
Qu LingBo,
Zhao YuFen
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.660
Subject(s) - chemistry , electrospray ionization , oligopeptide , mass spectrometry , peptide , chromatography , electrospray , quenching (fluorescence) , protein mass spectrometry , electrospray mass spectrometry , phosphorus , conjugated system , organic chemistry , biochemistry , fluorescence , physics , quantum mechanics , polymer
Abstract With the assistance of phosphorus oxychloride, α‐amino acids were assembled into homo‐peptides, which were analyzed by electrospray ionization mass spectrometry (ESI‐MS) and multistage electrospray ionization mass spectrometry (ESI‐MS/MS). On quenching with water or various alcohols, the reaction mixtures yielded the corresponding peptides or peptide esters, respectively. This paper reports a simple method to synthesize the homo‐oligo‐peptide‐ester conjugated library by phosphorus oxychloride activation. Copyright © 2002 John Wiley & Sons, Ltd.