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Electrospray ionisation and ion‐trap fragmentation of substituted 3,4‐dihydro‐2(1 H )‐pyridin‐2‐ones
Author(s) -
Suárez M.,
MartínezAlvarez R.,
Martín N.,
Verdecia Y.,
Ochoa E.,
Alba L.,
Seoane C.,
Kayali N.
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.634
Subject(s) - chemistry , fragmentation (computing) , electrospray , electron ionization , ion , electrospray ionization , ionization , analytical chemistry (journal) , aryl , mass spectrum , mass spectrometry , polyatomic ion , ion trap , organic chemistry , chromatography , alkyl , computer science , operating system
A variety of 5‐alkoxycarbonyl‐4‐aryl‐6‐methyl‐3,4‐dihydro‐2(1 H )‐pyridones and hexahydrofuro[3,4‐ b ]‐2(1 H )‐pyridones have been investigated by electron impact (EI) and electrospray ionisation (ESI) techniques. Sequential product ion fragmentation (MS n ) was performed to elucidate the degradation pathways for these compounds. Comparisons are made between positive and negative even‐electron ions from ESI spectra and the molecular radical cations obtained under EI conditions. The data collected in this paper provide information on the strong impact that different substituents have on the ion fragmentation process. Copyright © 2002 John Wiley & Sons, Ltd.