Atmospheric pressure laser desorption/chemical ionization mass spectrometry: a new ionization method based on existing themes | Zendy

Coon Joshua J. | Zendy; McHale Kevin J. | Zendy; Harrison W. W. | Zendy

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Atmospheric pressure laser desorption/chemical ionization mass spectrometry: a new ionization method based on existing themes

Author(s) -

Coon Joshua J.,

McHale Kevin J.,

Harrison W. W.

Publication year - 2002

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.626

Subject(s) - chemistry , ambient ionization , soft laser desorption , ion source , atmospheric pressure laser ionization , mass spectrometry , matrix assisted laser desorption electrospray ionization , analytical chemistry (journal) , atmospheric pressure , ionization , desorption electrospray ionization , chemical ionization , ion , laser , desorption , atmospheric pressure chemical ionization , matrix assisted laser desorption/ionization , photoionization , thermal ionization mass spectrometry , chromatography , optics , oceanography , physics , organic chemistry , adsorption , geology

We have designed and constructed an atmospheric pressure laser desorption/chemical ionization (AP‐LD/CI) source that utilizes a laser pulse to desorb intact neutral molecules, followed by chemical ionization via reagent ions produced by a corona discharge. This source employs a heated capillary atmospheric pressure inlet coupled to a quadrupole ion trap mass spectrometer and allows sampling under normal ambient air conditions. Preliminary results demonstrate that this technique provides ∼150‐fold increase in analyte ions compared to the ion population generated by atmospheric pressure infrared matrix‐assisted laser desorption/ionization (AP‐IR‐MALDI). Copyright © 2002 John Wiley & Sons, Ltd.

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