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Determination of rare earth elements in urine by electrothermal vaporization inductively coupled plasma mass spectrometry
Author(s) -
Bettinelli Maurizio,
Spezia Sandro,
Terni Cesarina,
Ronchi Anna,
Balducci Claudio,
Minoia Claudio
Publication year - 2002
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.609
Subject(s) - chemistry , vaporization , inductively coupled plasma mass spectrometry , detection limit , mass spectrometry , urine , chromatography , inductively coupled plasma , analytical chemistry (journal) , calibration curve , lanthanide , plasma , ion , biochemistry , physics , organic chemistry , quantum mechanics
A method was developed for the determination of rare earth elements (REEs) in urine with electrothermal vaporization inductively coupled plasma mass spectrometry (ETV‐ICPMS). The undiluted sample was directly injected into the graphite tube and trifluoromethane (Freon‐23) was used as chemical modifier in order to reduce the vaporization temperature and the memory effect of most of the lanthanides. The detection limits were in the range 1–10 ng/L with relative standard deviation of 3–5% at concentration levels of 1µg/L, and less than 10–15% at 100 ng/L. Two different procedures, external calibration and a standard additions method, were evaluated to measure the concentration levels of lanthanides in the urine samples and the second procedure was considered to be the best choice for calibration in this work. The level of REEs in urine of 50 healthy volunteers was in the range 5–20 ng/L, above the detection limit of ETV‐ICPMS. Copyright © 2002 John Wiley & Sons, Ltd.