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Dual buffer gases for ion manipulation in a miniature ion trap mass spectrometer with a discontinuous atmospheric pressure interface
Author(s) -
Chen TsungChi,
Xu Wei,
Ouyang Zheng
Publication year - 2011
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.5226
Subject(s) - buffer gas , ion trap , chemistry , quadrupole ion trap , mass spectrometry , ion , atmospheric pressure , ion source , helium , analytical chemistry (journal) , fragmentation (computing) , hybrid mass spectrometer , dissociation (chemistry) , tandem mass spectrometry , atomic physics , selected reaction monitoring , optics , chromatography , physics , laser , organic chemistry , meteorology , computer science , operating system
The discontinuous atmospheric pressure interface (DAPI) has been developed to allow a direct transfer of ions from atmosphere into an ion trap mass spectrometer with minimum pumping capability. Air is introduced into the trap with ions and used as a buffer gas for the ion trap operation. In this study, a method of introducing helium as a second buffer gas was developed for a miniature mass spectrometer using a dual DAPI configuration. The buffer gas effects on the performance of a linear ion trap (LIT) with hyperbolic electrodes were characterized for ion isolation, fragmentation and a mass‐selective instability scan. Significant improvement was obtained with helium for resolutions of mass analysis and ion isolation, while moderate advantage was gained with air for collision‐induced dissociation. The buffer gas can be switched between air and helium for different steps within a single scan, which allows further optimization of the instrument performance for tandem mass spectrometry. Copyright © 2011 John Wiley & Sons, Ltd.