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The use of a triple quadrupole linear ion trap mass spectrometer with electrospray ionisation for fragmentation studies of selected antifungal drugs
Author(s) -
ZgołaGrześkowiak Agnieszka,
Grześkowiak Tomasz
Publication year - 2011
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.5188
Subject(s) - fragmentation (computing) , chemistry , clioquinol , quadrupole ion trap , triple quadrupole mass spectrometer , fluconazole , electrospray , clotrimazole , mass spectrometry , ion trap , ion , antifungal , analytical chemistry (journal) , chromatography , selected reaction monitoring , tandem mass spectrometry , pharmacology , organic chemistry , medicine , dermatology , computer science , operating system
Fragmentation studies of three antifungal drugs, clotrimazole, fluconazole and clioquinol ,were performed. A triple quadrupole linear ion trap mass spectrometer was used for this purpose. This type of equipment enables MS 3 spectra to be obtained which lead to better understanding of fragmentation pathways. Nevertheless, it is rarely used for fragmentation studies. The results obtained here for the antifungal drugs gave further insight into fragmentation pathways of clotrimazole and fluconazole. Moreover, fragmentation of clioquinol was investigated which had not been presented before. Copyright © 2011 John Wiley & Sons, Ltd.