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An unusual kynurenine‐containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella . Sequence determination by electrospray mass spectrometry
Author(s) -
EllisSteinborner Simon T.,
Scanlon Denis,
Musgrave Ian F.,
Tran T. T. Nha,
Hack Sandra,
Wang Tianfang,
Abell Andrew D.,
Tyler Michael J.,
Bowie John H.
Publication year - 2011
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.5041
Subject(s) - chemistry , peptide , tree frog , electrospray , secretion , mass spectrometry , chromatography , zoology , biochemistry , biology
The Kyn‐containing peptide FP‐Kyn‐L(NH 2 ) is an unusual minor component of the skin peptide profile of the Australian red tree frog Litoria rubella collected from an area within a 20 kilometre radius of Alice Springs in central Australia. The structure was determined by electrospray mass spectrometry and synthesis. The major component of the skin secretion is the analogous tryptophyllin peptide FPWL(NH 2 ). Both peptides show opioid activity at 10 –7 M, and are likely to act via the μ opioid receptor. Copyright © 2011 John Wiley & Sons, Ltd.