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Liquid chromatography/atmospheric pressure photoionization tandem mass spectrometry for analysis of Dechloranes
Author(s) -
Zhou Simon Ningsun,
Reiner Eric J.,
Marvin Chris H.,
Helm Paul A.,
Shen Li,
Brindle Ian D.
Publication year - 2011
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4874
Subject(s) - chemistry , chromatography , atmospheric pressure chemical ionization , photoionization , mass spectrometry , direct electron ionization liquid chromatography–mass spectrometry interface , atmospheric pressure , analytical chemistry (journal) , ionization , tandem mass spectrometry , electrospray ionization , liquid chromatography–mass spectrometry , chemical ionization , ion , organic chemistry , oceanography , geology
Liquid chromatography/atmospheric pressure photoionization tandem mass spectrometry (LC/APPI‐MS/MS) was investigated as an instrumental method for the analysis of the halogenated norbornene flame retardants, Mirex, Dechloranes 602, 603, 604, and Dechlorane Plus (DP). The LC separation was optimized by screening a variety of stationary and mobile phases, resulting in a short LC separation time of 5 min. Different atmospheric pressure ionization approaches were examined including electrospray ionization, atmospheric pressure chemical ionization, and APPI, each with and without post‐column addition. APPI without post‐column addition was chosen for providing the best ionization response. The optimized LC/APPI‐MS/MS approach resulted in instrument detection limits ranging between 25 and 50 pg. Good linearity was also achieved (up to 25.0 ng/µL; R >0.999). The method was applied to extracts of environmental samples including surface water, fish and sediments for screening purposes, and the results agreed well with those obtained by gas chromatography/mass spectrometry. Copyright © 2011 John Wiley & Sons, Ltd.