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Electrospray ionization mass spectrometric fragmentation of hydroquinone derivatives
Author(s) -
Almodóvar Iriux,
RamírezRodríguez Oney,
Barriga Andrés,
Rezende Marcos Caroli,
ArayaMaturana Ramiro
Publication year - 2010
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4868
Subject(s) - chemistry , fragmentation (computing) , homolysis , steric effects , intramolecular force , electrospray ionization , hydroquinone , mass spectrometry , electrospray , nucleophilic aromatic substitution , nucleophilic substitution , stereochemistry , photochemistry , computational chemistry , medicinal chemistry , organic chemistry , radical , chromatography , computer science , operating system
The fragmentation patterns of nine di‐, tri‐ and tetracyclic hydroquinones with potential antitumor activity were rationalized by invoking competing mechanisms that included sterically accelerated homolytic cleavage, Meerwein‐type rearrangements and dehydrations through elimination or intramolecular nucleophilic substitution. Copyright © 2010 John Wiley & Sons, Ltd.