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Liquid chromatography/electrospray time‐of‐flight mass spectrometry for the characterisation of cyclic phosphazenes
Author(s) -
Veldboer Katrin,
Schürmann Thomas,
Vogel Martin,
Wiemhöfer HansDieter,
Karst Uwe
Publication year - 2010
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4837
Subject(s) - chemistry , mass spectrometry , electrospray , electrospray mass spectrometry , chlorine , electrospray ionization , chlorine atom , chromatography , nuclear magnetic resonance spectroscopy , mass spectrum , organic chemistry , medicinal chemistry
Cyclic phosphazenes with different substituents were synthesised and investigated by liquid chromatography (LC) and electrospray ionisation mass spectrometry (ESI‐MS). Hexachlorocyclotriphosphazene was functionalised with aliphatic substituents as alcohols and amines, leading to product mixtures, which were subsequently analysed. In contrast to classical methods of structural analysis such as nuclear magnetic resonance (NMR) spectroscopy or X‐ray crystallography, which are restricted to pure compounds, these complex mixtures can favourably be analysed by means of LC/ESI‐MS. The main products could be separated from by‐products and, moreover, all the components of the unknown mixture were unambiguously identified by accurate mass measurements. For all compounds with different side‐chain ratios, remaining chlorine atoms or hydroxyl groups and even for spiro or ansa products, molecular structures could be suggested. Copyright © 2010 John Wiley & Sons, Ltd.