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High‐sensitivity negative‐ion laser spray for liquid chromatography/mass spectrometry
Author(s) -
Hiraoka Kenzo,
Asakawa Yoshiki,
Yamamoto Yasuteru,
Nakamura Masana,
Ueda Kazuhiro
Publication year - 2001
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.473
Subject(s) - chemistry , mass spectrometry , chromatography , electrospray , ion , mass spectrum , analytical chemistry (journal) , laser , organic chemistry , physics , optics
A negative‐ion mode laser spray interface for use in liquid chromatography/mass spectrometry (LC/MS) has been developed and investigated. The laser spray gave sensitivities that were orders of magnitude better than the negative‐ion electrospray for all samples investigated with the exception of sugars. Fragment ions, HSO 4 − and SO 3 − , were formed from the laser‐sprayed aqueous solution of cholesterol 3‐sulfate sodium salt. This suggests that structural information may be obtained directly from the laser‐spray mass spectra for thermally labile compounds. Copyright © 2001 John Wiley & Sons, Ltd.