Ultrasound ionization of biomolecules | Zendy

Wu ChenI | Zendy; Wang YiSheng | Zendy; Chen Nelson G. | Zendy; Wu ChungYi | Zendy; Chen ChungHsuan | Zendy

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Ultrasound ionization of biomolecules

Author(s) -

Wu ChenI,

Wang YiSheng,

Chen Nelson G.,

Wu ChungYi,

Chen ChungHsuan

Publication year - 2010

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.4677

Subject(s) - chemistry , biomolecule , ionization , ultrasound , nanotechnology , organic chemistry , biochemistry , ion , acoustics , physics , materials science

To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix‐assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright © 2010 John Wiley & Sons, Ltd.

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