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Ultrasound ionization of biomolecules
Author(s) -
Wu ChenI,
Wang YiSheng,
Chen Nelson G.,
Wu ChungYi,
Chen ChungHsuan
Publication year - 2010
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4677
Subject(s) - chemistry , biomolecule , ionization , ultrasound , nanotechnology , organic chemistry , biochemistry , ion , acoustics , physics , materials science
To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix‐assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright © 2010 John Wiley & Sons, Ltd.