Electrospray ionization mass spectrometry probing of formation and recognition of the G‐quadruplex in the proximal promoter of the human vascular endothelial growth factor gene | Zendy

Li Huihui | Zendy; Yuan Gu | Zendy

Premium

Electrospray ionization mass spectrometry probing of formation and recognition of the G‐quadruplex in the proximal promoter of the human vascular endothelial growth factor gene

Author(s) -

Li Huihui,

Yuan Gu

Publication year - 2010

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.4613

Subject(s) - chemistry , electrospray ionization , g quadruplex , mass spectrometry , vascular endothelial growth factor , electrospray , gene , stereochemistry , vegf receptors , chromatography , dna , biochemistry , cancer research , biology

The formation of the G‐quadruplex of the vascular endothelial growth factor (VEGF) gene was probed by electrospray ionization mass spectrometry (ESI‐MS). It found that cations (K + and NH 4 + ), CH 3 OH and pH influence significantly the formation of the G‐quadruplex structure. Additionally, a perylene derivative (P3) and polydatin (P4) have shown to be potential G‐quadruplex binding agents with structurally specific recognition. Copyright © 2010 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research