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Electrospray ionization mass spectrometry probing of formation and recognition of the G‐quadruplex in the proximal promoter of the human vascular endothelial growth factor gene
Author(s) -
Li Huihui,
Yuan Gu
Publication year - 2010
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4613
Subject(s) - chemistry , electrospray ionization , g quadruplex , mass spectrometry , vascular endothelial growth factor , electrospray , gene , stereochemistry , vegf receptors , chromatography , dna , biochemistry , cancer research , biology
The formation of the G‐quadruplex of the vascular endothelial growth factor (VEGF) gene was probed by electrospray ionization mass spectrometry (ESI‐MS). It found that cations (K + and NH 4 + ), CH 3 OH and pH influence significantly the formation of the G‐quadruplex structure. Additionally, a perylene derivative (P3) and polydatin (P4) have shown to be potential G‐quadruplex binding agents with structurally specific recognition. Copyright © 2010 John Wiley & Sons, Ltd.