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Behaviour of tetraalkylammonium ions in high‐field asymmetric waveform ion mobility spectrometry
Author(s) -
Aksenov Alexander A.,
Kapron James T.
Publication year - 2010
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4539
Subject(s) - chemistry , ion mobility spectrometry , ion , mass spectrometry , waveform , ion mobility spectrometry–mass spectrometry , analytical chemistry (journal) , chromatography , thermal ionization mass spectrometry , ion source , aerospace engineering , organic chemistry , radar , engineering
High‐field asymmetric waveform ion mobility spectrometry (FAIMS) is an ion‐filtering technique recently adapted for use with liquid chromatography/mass spectrometry (LC/MS) to remove interferences during analysis of complex matrices. This is the first systematic study of a series of singly charged tetraalkylammonium ions by FAIMS‐MS. The compensation voltage (CV) is the DC offset of the waveform which permits the ion to emerge from FAIMS and it was determined for each member of the series under various conditions. The electrospray ionization conditions explored included spray voltage, vaporizer temperature, and sheath and auxiliary gas pressure. The FAIMS conditions explored included carrier gas flow rate, electrode temperature and composition of the carrier gas. Optimum desolvation was achieved using sufficient carrier gas (flow rate ≥2 L/min) to ensure stable response. Low‐mass ions ( m/z 100–200) are more susceptible to changes in electrode temperature and gas composition than high mass ions ( m/z 200–700). As a result of this study, ions are reliably analyzed using standard FAIMS conditions (dispersion voltage −5000 V, carrier gas flow rate 3 L/min, 50% helium/50%nitrogen, inner electrode temperature 70°C and outer electrode temperature 90°C). Variation of FAIMS conditions may be of great use for the separation of very low mass tetraalkylammonium (TAA) ions from other TAA ions. The FAIMS conditions do not appear to have a major effect on higher mass ions. Copyright © 2010 John Wiley & Sons, Ltd.