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Mass spectrometry and UV‐VIS spectrophotometry of ruthenium(II) [RuClCp(mPTA) 2 ](OSO 2 CF 3 ) 2 complex in solution
Author(s) -
PeñaMéndez Eladia María,
González Beatriz,
Lorenzo Pablo,
Romerosa Antonio,
Havel Josef
Publication year - 2009
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4323
Subject(s) - chemistry , ruthenium , aqueous solution , spectrophotometry , hydroxide , mass spectrometry , hydrochloric acid , chloride , inorganic chemistry , hydrolysis , analytical chemistry (journal) , nuclear chemistry , chromatography , catalysis , biochemistry , organic chemistry
Ruthenium(II) complexes are of great interest as a new class of cancerostatics with advantages over classical platinum compounds including lower toxicity. The stability of the [RuClCp(mPTA) 2 ](OSO 2 CF 3 ) 2 complex (I) (Cp cyclopentadienyl, mPTA N ‐methyl 1,3,5‐triaza‐7‐phosphaadamantane) in aqueous solution was studied using spectrophotometry, matrix‐assisted laser desorption/ionization (MALDI) and laser desorption/ionization (LDI) time‐of‐flight (TOF) mass spectrometry (MS). Spectrophotometry proves that at least three different reactions take place in water. Dissolution of I leads to fast coordination of water molecules to the Ru(II) cation and then slow hydrolysis and ligand exchange of chloride and mPTA with water, hydroxide or with trifluoromethane sulfonate itself. Via MALDI and LDI of the hydrolyzed solutions the formation of singly positively charged ions of general formula RuCl p (Cp) q (mPTA) r (H 2 O) s (OH) t ( p = 0–1, q = 0–1, r = 0–2, s = 0–5, t = 0–2) and of some fragment ions was shown. The stoichiometry was determined by analyzing the isotopic envelopes and computer modelling. The [RuClCp(mPTA) 2 ](OSO 2 CF 3 ) 2 complex can be stabilized in dilute hydrochloric acid or in neutral 0.15 M isotonic sodium chloride solution. Copyright © 2009 John Wiley & Sons, Ltd.