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Derivatization aids in the determination of end groups in poly(alkylene glycol)s by matrix‐assisted laser desorption/ionization mass spectrometry
Author(s) -
Borisov Roman S.,
Polovkov Nikolai Yu.,
Zaikin Vladimir G.
Publication year - 2009
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4251
Subject(s) - chemistry , derivatization , bstfa , mass spectrometry , trimethylsilyl , matrix assisted laser desorption/ionization , mass spectrum , derivative (finance) , chemical ionization , desorption , chromatography , analytical chemistry (journal) , ionization , organic chemistry , ion , adsorption , financial economics , economics
A method for end‐group characterization by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry following preliminary derivatization with N,O ‐bis(trimethylsilyl)trifluoroacetamide (BSTFA) and capryloyl chloride is described and applied to poly(alkylene glycol)s. The MALDI mass spectra of the products revealed peaks of sodiated derivative cations, whose shift by the respective increments allowed the determination of the number of end functional groups with active hydrogens. This approach is particularly efficient for the distinction of cyclic and linear dehydration products among minor components. Copyright © 2009 John Wiley & Sons, Ltd.