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Sterically hindered phenols in negative ion mobility spectrometry–mass spectrometry
Author(s) -
Laakia Jaakko,
Pedersen Christian Schack,
Adamov Alexey,
Viidanoja Jyrki,
Sysoev Alexey,
Kotiaho Tapio
Publication year - 2009
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4223
Subject(s) - chemistry , ion mobility spectrometry , mass spectrometry , analytical chemistry (journal) , ion , atmospheric pressure chemical ionization , mass spectrum , polyatomic ion , ion mobility spectrometry–mass spectrometry , phenols , chemical ionization , ionization , chromatography , organic chemistry , thermal ionization mass spectrometry
Negative corona discharge atmospheric pressure chemical ionization (APCI) was used to investigate phenols with varying numbers of tert ‐butyl groups using ion mobility spectrometry–mass spectrometry (IMS‐MS). The main characteristic ion observed for all the phenolic compounds was the deprotonated molecule [M–H] − . 2‐ tert ‐Butylphenol showed one main mobility peak in the mass‐selected mobility spectrum of the [M–H] − ion measured under nitrogen atmosphere. When air was used as a nebulizer gas an oxygen addition ion was seen in the mass spectrum and, interestingly, this new species [M–H+O] − had a shorter drift time than the lighter [M–H] − ion. Other phenolic compounds primarily produced two IMS peaks in the mass‐selected mobility spectra measured using the [M–H] − ion. It was also observed that two isomeric compounds, 2,4‐di‐ tert ‐butylphenol and 2,6‐di‐ tert ‐butylphenol, could be separated with IMS. In addition, mobilities of various characteristic ions of 2,4,6‐trinitrotoluene were measured, since this compound was previously used as a mobility standard. The possibility of using phenolic compounds as mobility standards is also discussed. Copyright © 2009 John Wiley & Sons, Ltd.