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Atmospheric pressure infrared (10.6 µm) laser desorption electrospray ionization (IR‐LDESI) coupled to a LTQ Fourier transform ion cyclotron resonance mass spectrometer
Author(s) -
Sampson Jason S.,
Muddiman David C.
Publication year - 2009
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.4113
Subject(s) - chemistry , fourier transform ion cyclotron resonance , mass spectrometry , analytical chemistry (journal) , infrared , matrix assisted laser desorption electrospray ionization , ionization , atmospheric pressure , laser , desorption electrospray ionization , ion source , electrospray ionization , fourier transform infrared spectroscopy , ion cyclotron resonance , ion , atmospheric pressure laser ionization , photoionization , chemical ionization , chromatography , cyclotron , thermal ionization mass spectrometry , optics , physics , oceanography , organic chemistry , geology
We present the implementation of a CO 2 laser emitting infrared laser irradiation at 10.6 µm onto the versatile atmospheric pressure ionization platform. Infrared laser desorption electrospray ionization (IR‐LDESI) is demonstrated from liquid‐state samples at atmospheric pressure with and without ESI postionization. Multiply charged proteins ranging in molecular mass from 8.6 to 17 kDa were detected from liquid‐state samples without the addition of matrix. Copyright © 2009 John Wiley & Sons, Ltd.