Modification of a commercial electrospray nebulizer for operation in a liquid chromatography/mass spectrometry system at flow rates in the low µL/min range | Zendy

Carrier Alain | Zendy; Parent Josée | Zendy

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Modification of a commercial electrospray nebulizer for operation in a liquid chromatography/mass spectrometry system at flow rates in the low µL/min range

Author(s) -

Carrier Alain,

Parent Josée

Publication year - 2001

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.410

Subject(s) - nebulizer , chemistry , electrospray , chromatography , volumetric flow rate , mass spectrometry , liquid chromatography–mass spectrometry , analytical chemistry (journal) , electrospray mass spectrometry , medicine , physics , quantum mechanics , anesthesia

A simple and inexpensive approach to convert the electrospray nebulizer of a commercial liquid chromatography/mass spectrometry (LC/MS) system (HP 1100) to accommodate lower flow rates has been proposed and evaluated. This modification consists of simply replacing the nebulizer needle by a commercially available stainless steel needle with a smaller internal diameter. Experiments were conducted in order to optimize operational parameters. Using two different internal diameter needle sizes, flow rates ranging from 1 to 250 µL/min could be accommodated. The modification presented allows an extension of the range of compatible flow rates without major modification of the standard design of the interface. Copyright © 2001 John Wiley & Sons, Ltd.

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