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Matrix‐assisted laser desorption/ionization by using femtosecond laser pulses in the near‐infrared wavelength regime
Author(s) -
Wichmann J. M.,
Lupulescu C.,
Wöste L.,
Lindinger A.
Publication year - 2009
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3974
Subject(s) - matrix assisted laser desorption electrospray ionization , chemistry , laser , femtosecond , atmospheric pressure laser ionization , ionization , soft laser desorption , ultraviolet , far infrared laser , infrared , ambient ionization , absorption (acoustics) , wavelength , desorption , matrix assisted laser desorption/ionization , photoionization , optics , ion , chemical ionization , physics , electron ionization , organic chemistry , adsorption
We observe a substantial matrix‐assisted laser desorption/ionization (MALDI) signal when irradiating femtosecond laser pulses in the near‐infrared spectral range centered around 800 nm and using standard MALDI matrices with absorption bands in the ultraviolet (UV) regime. The laser pulse energy dependence of this novel phenomenon is investigated in comparison with MALDI with near‐UV laser pulses. Our observations show that multiphoton absorption/ionization could be a major issue among the MALDI processes when the sample is irradiated with ultra‐short laser pulses. Copyright © 2009 John Wiley & Sons, Ltd.