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Titanium dioxide anatase as matrix for matrix‐assisted laser desorption/ionization analysis of small molecules
Author(s) -
Castro Ana L.,
Madeira Paulo J. Amorim,
Nunes Manuel R.,
Costa Fernanda M.,
Florêncio M. Helena
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3795
Subject(s) - anatase , chemistry , rutile , desorption , matrix (chemical analysis) , titanium dioxide , mass spectrometry , matrix assisted laser desorption/ionization , mass spectrum , analytical chemistry (journal) , matrix assisted laser desorption electrospray ionization , chemical engineering , molecule , ion , chromatography , organic chemistry , photocatalysis , adsorption , catalysis , engineering
The use of inorganic species as assisting materials in matrix‐assisted laser desorption/ionization (MALDI) analysis is an alternative approach to avoid interfering matrix ions in the low‐mass region of the mass spectra. Reports of the application of inorganic species as matrices in MALDI analysis of small molecules are, however, scarce. Nevertheless, titanium dioxide (TiO 2 ) powder has been reported to be a promising matrix medium. In this study we further explore the use of TiO 2 as a matrix for the MALDI analysis of low molecular weight compounds. We present results showing that nanosized TiO 2 anatase and TiO 2 rutile perform better as MALDI matrices than a commercial TiO 2 anatase/rutile mixture. Moreover, when using nanosized TiO 2 anatase as a matrix, high‐quality mass spectra can be obtained with strong analyte signals and weak or non‐existing matrix interference ions. Furthermore, our results show that the phase type plays an important role in the application of TiO 2 as a MALDI matrix. Copyright © 2008 John Wiley & Sons, Ltd.