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Detection and assessment of co‐association in inhalable drug particles using aerosol time‐of‐flight mass spectrometry
Author(s) -
New Anthony,
Prime Dave,
Zomer Simeone,
Elder David,
Donovan Robert,
Freney Evelyn
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3774
Subject(s) - chemistry , aerosol , mass spectrometry , inhaler , dry powder inhaler , fluticasone propionate , chromatography , time of flight mass spectrometry , chemiluminescence , drug , pharmacology , inhalation , asthma , organic chemistry , medicine , anatomy , ion , ionization
Aerosol Time‐of‐Flight Mass Spectrometry (AToFMS) was used to examine co‐association between two inhaled drugs, fluticasone propionate (FP) and salmeterol xinofoate (SX), in fine aerosolised particles emitted from Seretide®/Advair® inhaled combination products. Principal Component Analysis (PCA) was used to identify fragmentation patterns indicative of either pure or co‐associated particles (particles containing both drugs). A third component of the particles emitted from dry powder inhalers (DPIs), lactose, gave only a very weak mass spectral signal and no interpretable data was acquired for this compound; however, it was not found to interfere with the detection of the two drug substances. High levels of co‐association were found in the emitted doses from both pressurised metered dose inhaler (pMDI) and dry powder inhaler (DPI) products. Copyright © 2008 John Wiley & Sons, Ltd.