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Characterization by mass spectrometry of an unknown polysiloxane sample used under uncontrolled medical conditions for cosmetic surgery
Author(s) -
Schneider Cédric,
Sablier Michel,
Desmazières Bernard
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3741
Subject(s) - chemistry , mass spectrometry , chromatography , atmospheric pressure chemical ionization , mass spectrum , analytical chemistry (journal) , electrospray , electrospray ionization , sample preparation in mass spectrometry , sample preparation , ionization , chemical ionization , organic chemistry , ion
For a complete understanding of the raw material used for cosmetic surgery under uncontrolled medical conditions, an unknown sample of polydimethylsiloxanes has been investigated utilizing a combination of analytical techniques: pyrolysis/gas chromatography/mass spectrometry (Py/GC/MS), electrospray ionization (ESI)‐MS, matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF)MS, and liquid chromatography (LC)/MS. Among these techniques, the LC/APCI‐MS coupling allowed the fastest and more effective analysis. In addition, the complexity of the mass spectra deduced from these LC/MS experiments was simplified compared to the mass spectra obtained by MALDI‐TOF. In this work, we have demonstrated how the LC/APCI‐MS coupling applied to polydimethylsiloxane samples permits the full characterization of samples where end groups of different nature can be present in very small quantities. Copyright © 2008 John Wiley & Sons, Ltd.