Characterization by mass spectrometry of an unknown polysiloxane sample used under uncontrolled medical conditions for cosmetic surgery | Zendy

Schneider Cédric | Zendy; Sablier Michel | Zendy; Desmazières Bernard | Zendy

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Characterization by mass spectrometry of an unknown polysiloxane sample used under uncontrolled medical conditions for cosmetic surgery

Author(s) -

Schneider Cédric,

Sablier Michel,

Desmazières Bernard

Publication year - 2008

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.3741

Subject(s) - chemistry , mass spectrometry , chromatography , atmospheric pressure chemical ionization , mass spectrum , analytical chemistry (journal) , electrospray , electrospray ionization , sample preparation in mass spectrometry , sample preparation , ionization , chemical ionization , organic chemistry , ion

For a complete understanding of the raw material used for cosmetic surgery under uncontrolled medical conditions, an unknown sample of polydimethylsiloxanes has been investigated utilizing a combination of analytical techniques: pyrolysis/gas chromatography/mass spectrometry (Py/GC/MS), electrospray ionization (ESI)‐MS, matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF)MS, and liquid chromatography (LC)/MS. Among these techniques, the LC/APCI‐MS coupling allowed the fastest and more effective analysis. In addition, the complexity of the mass spectra deduced from these LC/MS experiments was simplified compared to the mass spectra obtained by MALDI‐TOF. In this work, we have demonstrated how the LC/APCI‐MS coupling applied to polydimethylsiloxane samples permits the full characterization of samples where end groups of different nature can be present in very small quantities. Copyright © 2008 John Wiley & Sons, Ltd.

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