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Selected ion flow tube mass spectrometry of exhaled breath condensate headspace
Author(s) -
Čáp Petr,
Dryahina Kseniya,
Pehal František,
Španěl Patrik
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3685
Subject(s) - chemistry , exhaled breath condensate , breath gas analysis , acetaldehyde , formaldehyde , chromatography , isoprene , methanol , acetone , mass spectrometry , ethanol , environmental chemistry , organic chemistry , medicine , asthma , copolymer , polymer
Collection of exhaled breath condensate (EBC) is a relatively simple noninvasive method of breath analysis; however, no data have been reported that would relate concentration of volatile compounds in EBC to their gaseous concentrations in exhaled air. The aim of the study was to investigate which volatile compounds are present in EBC and how their concentrations relate to results of direct breath analysis. Thus, samples of EBC were collected in a standard way from several subjects and absolute levels of several common volatile breath metabolites (ammonia, acetone, ethanol, methanol, propanol, isoprene, hydrogen cyanide, formaldehyde and acetaldehyde) were then determined in their headspace using selected ion flow tube mass spectrometry (SIFT‐MS). Results are compared with those from on‐line breath analyses carried out immediately before collecting the EBC samples. It has been demonstrated that SIFT‐MS can be used to quantify the concentrations of volatiles in EBC samples and that, for methanol, ammonia, ethanol and acetone, the EBC concentrations correlate with the direct breath levels. However, the EBC concentrations of isoprene, formaldehyde, acetaldehyde, hydrogen cyanide and propanol do not correlate with direct breath measurements. Copyright © 2008 John Wiley & Sons, Ltd.