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The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry
Author(s) -
Pan Yang,
Yin Hao,
Zhang Taichang,
Guo Huijun,
Sheng Liusi,
Qi Fei
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3639
Subject(s) - photoionization , chemistry , mass spectrometry , fragmentation (computing) , ionization , infrared , ion , photon energy , electron ionization , atmospheric pressure laser ionization , analytical chemistry (journal) , photon , optics , chromatography , physics , organic chemistry , computer science , operating system
Some selected drugs including captopril, fudosteine and racecadotril have been analyzed by infrared (IR) laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (PIMS). The molecular ions of captopril and racecadotril are exclusively observed without any fragments at near threshold single‐photon ionization (SPI). However, fudosteine easily forms fragments even at a photon energy near the ionization threshold, indicating the instability of its molecular ion. For these drugs, a number of fragments are yielded with the increase of photon energy. The structures of such fragments proposed by IR LD/VUV PIMS are supported by electron ionization time‐of‐flight mass spectrometry (EI‐TOFMS) results. Fragmentation pathways are discussed in detail. Copyright © 2008 John Wiley & Sons, Ltd.