Premium
Interactions of nucleosides with CrO 4 2− and Cr 3+ as studied by electrospray ionization mass spectrometry
Author(s) -
Frańska Magdalena,
Gierczyk Karolina
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3552
Subject(s) - chemistry , electrospray ionization , mass spectrometry , chromium , protonation , inorganic chemistry , molecule , medicinal chemistry , methanol , ion , organic chemistry , chromatography
The interactions of CrO 4 2−and Cr 3+ with nucleosides studied by electrospray ionization mass spectrometry (ESI‐MS) are reported. In water, the nucleosides which do not contain the NH 2 group form the unstable [M+HCrO 4 ] − anion. In the presence of a reducing agent, namely methanol, chromate anion forms stable complexes with nucleosides, [M+CH 3 CrO 4 ] − anions. The fragmentation of [M+CH 3 CrO 4 ] − anions involve elimination of the methanol molecule. Chromium cation‐nucleoside complexes were not observed in water. In methanol solutions, adenosine and cytidine form [(M−H)+CrOCH 3 ] + and [(M−H) 2 +Cr] + ions. Most probably, deprotonated imine tautomers form complexes in which a metal cation is simultaneously coordinated by two nitrogen atoms. Complexes containing chloride anions and a few methanol molecules were observed for other nucleosides. Guanosine and inosine form doubly charged ions of the type [M 2 +CrOCH 3 ] 2+ that probably contain a bond between the oxygen atom and the chromium cation, (HN(1)C(6)O) 2 …. Cr 3+ ). Copyright © 2008 John Wiley & Sons, Ltd.