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Sensitive determination of bromine and iodine in aqueous and biological samples by electrothermal vaporization inductively coupled plasma mass spectrometry using tetramethylammonium hydroxide as a chemical modifier
Author(s) -
Kataoka Hiroko,
Tanaka Sachiko,
Konishi Chie,
Okamoto Yasuaki,
Fujiwara Terufumi,
Ito Kazuaki
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3549
Subject(s) - chemistry , tetramethylammonium hydroxide , bromine , inductively coupled plasma mass spectrometry , vaporization , aqueous solution , iodine , mass spectrometry , detection limit , inductively coupled plasma , hydrobromic acid , iodide , certified reference materials , analytical chemistry (journal) , chromatography , hydroxide , inorganic chemistry , plasma , physics , organic chemistry , quantum mechanics
Abstract A procedure for the simultaneous determination of bromine and iodine by inductively coupled plasma (ICP) mass spectrometry was investigated. In order to prevent the decrease in the ionization efficiencies of bromine and iodine atoms caused by the introduction of water mist, electrothermal vaporization was used for sample introduction into the ICP mass spectrometer. To prevent loss of analytes during the drying process, a small amount of tetramethylammonium hydroxide solution was placed as a chemical modifier into the tungsten boat furnace. After evaporation of the solvent, the analytes instantly vaporized and were then introduced into the ICP ion source to detect the 79 Br + , 81 Br + , and 127 I + ions. By using this system, detection limits of 0.77 pg and 0.086 pg were achieved for bromine and iodine, respectively. These values correspond to 8.1 pg mL −1 and 0.91 pg mL −1 of the aqueous bromide and iodide ion concentrations, respectively, for a sampling volume of 95 µL. The relative standard deviations for eight replicate measurements were 2.2% and 2.8% for 20 pg of bromine and 2 pg of iodine, respectively. Approximately 25 batches were vaporizable per hour. The method was successfully applied to the analysis of various certified reference materials and practical situations as biological and aqueous samples. There is further potential for the simultaneous determination of fluorine and chlorine. Copyright © 2008 John Wiley & Sons, Ltd.