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Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry
Author(s) -
Lau Benjamin P.Y.,
Becalski Adam
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3547
Subject(s) - chemistry , chromatography , iodoacetic acid , derivatization , detection limit , electrospray , liquid chromatography–mass spectrometry , electrospray ionization , tandem mass spectrometry , mass spectrometry , selected reaction monitoring , extraction (chemistry) , organic chemistry , enzyme
A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized iodoacetic acid in water. The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 µg/L (or 0.3 ng/mL) and limit of quantitation was about 1 µg/L (1 ng/mL). Copyright © 2008 John Wiley & Sons, Ltd.