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Detection of monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry and their relevance as breath markers
Author(s) -
Senthilmohan Senti T.,
Kettle Anthony J,
McEwan Murray J.,
Dummer Jack,
Edwards Samuel J.,
Wilson Paul F.,
Epton Michael J.
Publication year - 2008
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3418
Subject(s) - chemistry , mass spectrometry , chromatography , tube (container) , analytical chemistry (journal) , mechanical engineering , engineering
We report a fast, sensitive, real‐time method to measure monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry (SIFT‐MS). Relative rate coefficients and product distributions are reported for the reagent ions H 3 O + and O 2 + . Rapid reactions with the haloamines were observed with H 3 O + and O 2 +but no fast reaction was found with NO + . A slow reaction between NO + and dichloramine was observed. We demonstrate the feasibility of determining these compounds in a single human breath for which the limit of detection is approaching 10 parts per billion (ppb). We also report preliminary measurements of these compounds in the breath of individuals where the concentrations of bromamine and chloramine ranged from 10 to 150 ppb. Copyright © 2008 John Wiley & Sons, Ltd.