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Matrix‐assisted laser desorption/ionization mechanism study with dihydroxybenzoic acid isomers as matrices
Author(s) -
Jessome Lori,
Hsu NienYeen,
Wang YiSheng,
Chen ChungHsuan
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3343
Subject(s) - chemistry , desorption , ionization , protonation , matrix assisted laser desorption electrospray ionization , soft laser desorption , matrix assisted laser desorption/ionization , proton affinity , atmospheric pressure laser ionization , matrix (chemical analysis) , biomolecule , analytical chemistry (journal) , gas phase , proton , chromatography , photoionization , organic chemistry , ion , adsorption , biochemistry , physics , quantum mechanics
Abstract Desorption and ionization efficiencies of matrix‐assisted laser desorption/ionization (MALDI) for various biolmolecules with different dihydroxybenzoic acid isomers were studied. No clear relationships were observed between MALDI biomolecule signals vs. gas‐phase basicity, proton affinity and ionization potential. This indicates the the gas‐phase protonation mechanism is not adequate to explain the observed results. Copyright © 2007 John Wiley & Sons, Ltd.