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Desorption electrospray ionization of aerosol particles
Author(s) -
Dong Jianan,
Rezenom Yohannes H.,
Murray Kermit K.
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3294
Subject(s) - chemistry , aerosol , electrospray , mass spectrometry , electrospray ionization , extractive electrospray ionization , analytical chemistry (journal) , ion trap , chromatography , desorption electrospray ionization , ion source , ionization , ambient ionization , solvent , ion , sample preparation in mass spectrometry , chemical ionization , thermal ionization mass spectrometry , organic chemistry
We have applied desorption electrospray ionization to aerosol particles. Ions were formed from aerosols by merging suspended dry particles with an electrospray of solvent in a modified ion trap mass spectrometer. Dry aerosol particles were generated using a fluidized bed powder disperser and directed toward the inlet of the mass spectrometer. A nanospray source was used to create a spray of solvent droplets directed at the inlet and at a right angle with respect to the aerosol. Ions generated by the interaction of the particles and electrospray were transferred into the ion trap mass spectrometer. Using this method, pure samples of caffeine and erythromycin A were analyzed. In addition, commonly available food and drug powders including instant cocoa powder, artificial sweetener and ibuprofen were analyzed. Copyright © 2007 John Wiley & Sons, Ltd.