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The non‐destructive identification of solid over‐the‐counter medications using single particle aerosol mass spectrometry
Author(s) -
Martin Audrey N.,
Farquar George R.,
Jones A. Daniel,
Frank Matthias
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3248
Subject(s) - chemistry , aerosol , mass spectrometry , particle (ecology) , chromatography , particle counter , analytical chemistry (journal) , organic chemistry , oceanography , geology
Single over‐the‐counter medication tablets were analyzed in real time using Single Particle Aerosol Mass Spectrometry (SPAMS). Dual‐polarity time‐of‐flight mass spectra were obtained for micrometer‐sized single particles dislodged from a single tablet without destroying the shape or markings of each tablet. The solid tablet was placed in a modified‐top glass vial and shaken to dislodge and introduce micrometer‐sized particles into the SPAMS system. Unique spectra from these particles were obtained in less than 1 s for single tablets of aspirin, ibuprofen, pseudoephedrine, phenylephrine, loratadine, or diphenhydramine. The signals obtained allowed the non‐destructive identification of an individual tablet in seconds. SPAMS presents an ideal system for high‐throughput analysis of solid drugs. Copyright © 2007 John Wiley & Sons, Ltd.