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Experimental investigation of mass analysis using an island of stability with a quadrupole with 2.0% added octopole field
Author(s) -
Moradian Annie,
Douglas D. J.
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3224
Subject(s) - chemistry , quadrupole , excitation , stability (learning theory) , analytical chemistry (journal) , resolution (logic) , position (finance) , polarity (international relations) , field (mathematics) , atomic physics , computational physics , physics , chromatography , mathematics , finance , quantum mechanics , machine learning , artificial intelligence , computer science , pure mathematics , economics , biochemistry , cell
We describe experimental investigations of mass analysis using an island of stability with a linear quadrupole with a 2.0% added octopole field. The island is formed by auxiliary quadrupole excitation. The experiments confirm the results of previous computer simulations (Konenkov et al., J. Am. Soc. Mass Spectrom. 2007; 18: 826–834). With the resolving direct current (dc) applied to the quadrupole so that the Mathieu parameter a > 0, conventional mass analysis with applied radio‐frequency (rf) and dc and no auxiliary excitation is possible. In this case, use of an island of stability yields similar peak shape and resolution. However, with the polarity of the resolving dc reversed, so that a < 0, only very low resolution can be obtained; the added octopole prevents conventional mass analysis. By using a stability island when a < 0, the resolution is substantially improved. In this case the use of an island allows mass analysis under conditions where the added octopole field severely degrades conventional analysis. The experiments also confirm the position of the island predicted by the simulations. Copyright © 2007 John Wiley & Sons, Ltd.