Characterization of the trace‐level impurities in the bulk drug citalopram by high‐performance liquid chromatography/tandem multistage mass spectrometry | Zendy

Sun Cuirong | Zendy; Xu Hui | Zendy; Pan Yuanjiang | Zendy; Shen Zhiquan | Zendy; Wang Danhua | Zendy

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Characterization of the trace‐level impurities in the bulk drug citalopram by high‐performance liquid chromatography/tandem multistage mass spectrometry

Author(s) -

Sun Cuirong,

Xu Hui,

Pan Yuanjiang,

Shen Zhiquan,

Wang Danhua

Publication year - 2007

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.3163

Subject(s) - chemistry , chromatography , tandem mass spectrometry , impurity , mass spectrometry , tandem , trace (psycholinguistics) , liquid chromatography–mass spectrometry , characterization (materials science) , analytical chemistry (journal) , nanotechnology , organic chemistry , materials science , composite material , linguistics , philosophy

Five trace impurities were detected in the bulk drug citalopram using high‐performance liquid chromatography with UV detection. A simple and sensitive method suitable for liquid chromatography tandem multistage mass spectrometry (HPLC/MS n ) analysis was developed. Using this method, the fragmentation behavior of citalopram and the impurities was investigated. Four impurities were rapidly characterized, and an unknown impurity was elucidated as 3‐(3‐dimethylaminopropyl)‐ N ‐(1‐(3‐dimethylaminopropyl)‐1‐(4‐fluorophenyl)‐1,3‐dihydroisobenzofuran‐5‐yl)‐3‐(4‐fluorophenyl)‐1,3‐dihydroisobenzofuran‐5‐carboxamide on the basis of the MS n and exact mass evidence, and the proposed structure was further confirmed by nuclear magnetic resonance (NMR) experiments after preparative isolation. Copyright © 2007 John Wiley & Sons, Ltd.

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