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A novel software tool for copolymer characterization by coupling of liquid chromatography with matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Author(s) -
Weidner Steffen M.,
Falkenhagen Jana,
Maltsev Sergey,
Sauerland Volker,
Rinken Marian
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3146
Subject(s) - copolymer , chemistry , mass spectrometry , chromatography , desorption , time of flight mass spectrometry , ionization , polypropylene , matrix assisted laser desorption/ionization , analytical chemistry (journal) , matrix (chemical analysis) , adsorption , polymer , organic chemistry , ion
The results of copolymer characterization by coupling of chromatography and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) techniques and subsequent calculation of copolymer composition using a novel software tool ‘MassChrom2D ’ are presented. For high‐resolution mass analysis copolymer samples were fractionated by means of liquid adsorption chromatography (LAC). These fractions were investigated off‐line by MALDI‐TOF MS. Various mono‐n‐butyl ethers of polyethylene oxide‐polypropylene oxide copolymers (PEO‐ co ‐PPO) were investigated. As well as the copolymer composition presented in two‐dimensional plots, the applied approach can give additional hints on specific structure‐dependent separation conditions in chromatography. Copyright © 2007 John Wiley & Sons, Ltd.