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Combining energy‐dependent electrospray ionisation with tandem mass spectrometry for the analysis of inorganic compounds
Author(s) -
Dyson Paul J.,
Hearley Andrew K.,
Johnson Brian F. G.,
McIndoe J. Scott,
LangridgeSmith Patrick R. R.,
Whyte Christopher
Publication year - 2001
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.314
Subject(s) - chemistry , mass spectrometry , electrospray , fragmentation (computing) , tandem mass spectrometry , electrospray ionization , triple quadrupole mass spectrometer , collision induced dissociation , analytical chemistry (journal) , tandem , protein mass spectrometry , hybrid mass spectrometer , sample preparation in mass spectrometry , quadrupole , chromatography , selected reaction monitoring , atomic physics , materials science , physics , computer science , composite material , operating system
The recently developed technique of energy‐dependent electrospray ionisation mass spectrometry (EDESI‐MS) has been implemented on a triple quadrupole mass spectrometer such that fragmentation occurs in the collision cell rather than at the skimmer cone. This modification enables a superior two‐dimensional map of the collision voltage versus mass‐to‐charge ratio to be generated, providing unambiguous peak assignments. This latest enhancement to the technique is referred to as energy‐dependent electrospray ionisation tandem mass spectrometry (EDESI‐MS/MS). In the present work the technique has been applied to investigate the sequential removal of ligands from the inorganic mixed‐metal anionic cluster compound [Ru 5 CoC(CO) 16 ] − , which serves to illustrate the advantages of this approach. Copyright © 2001 John Wiley & Sons, Ltd.