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Structural analysis of poly[( R,S )‐3‐hydroxybutyrate‐ co ‐L‐lactide] copolyesters by electrospray ionization ion trap mass spectrometry
Author(s) -
Adamus Grazyna
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3111
Subject(s) - copolyester , chemistry , electrospray ionization , mass spectrum , fragmentation (computing) , mass spectrometry , electrospray , diol , polymer chemistry , organic chemistry , polyester , chromatography , computer science , operating system
Two random copolyesters of poly[( R,S )‐3‐hydroxybutyrate‐ co ‐ L ‐lactide] (P[(R,S)‐3HB‐co‐LA]), prepared by equimolar reaction of ( R,S )‐β‐butyrolactone with L ‐lactic acid and ( R,S )‐3‐hydroxybutyric acid with L ‐lactide, respectively, were characterized by electrospray ionization ion trap mass spectrometry (ESI‐ITMS). Detailed studies of these copolyesters were performed by means of collision‐induced dissociation (CID). The molecular architecture of individual copolyester macromolecules, including chemical structures of their end groups (hydroxyl and carboxylate), were established on the basis of their ESI mass spectra. The influence of an intermolecular transesterification reaction on the microstructure of the copolyester synthesized by equimolar reaction of ( R,S )‐3‐hydroxybutyric acid with L ‐lactide was observed. The mass spectra provided information on sequence distribution and indicated that, despite the synthetic pathway applied, random P[(R,S)‐3HB‐co‐LA] copolyesters were formed predominantly. The arrangements of comonomer structural units along the copolyester chains were evaluated by the respective ESI‐MS/MS fragmentation pathways. Copyright © 2007 John Wiley & Sons, Ltd.